Paul Edwards concludes his chapter ‘The Semantic Challenge’ in his book God and the Philosophers with the following observation about logical positivism:

It is not uncommon nowadays to hear logical positivism dismissed as a set of crude errors and confusions. This is done with an air condescension by philosophers whose writings are usually models of obscurity. To people of my generation who came to philosophy in the 1940s, when traditional metaphysicians  were a dominating force, logical positivism was a liberating movement. Occasionally the leading figures were guilty of dogmatism, and on some important issues, such as the mind body problem and the question of free will, the logical positivists made no significant contributions, but the main doctrines seem to me substantially sound. The verification principle in particular, when stated with suitable amendments, is a powerful weapon against pretentious humbug.

Do life extensionists need to take an interest in philosophy of science and metaphysics? In his review of James Ladyman and Don Ross’s Every Thing Must Go: Metaphysics Naturalized, Alcor staff member Mike Perry notes that “as immortalists we hope to be in the world for a good long while, thus we are interested in the nature of reality. Reality determines, among other things, what our prospects are for our own longterm survival.”

Alternatively, one could argue that metaphysics is not a theoretically legitimate discipline and that the verifiable claims of physics exhaust what we can say about “reality.” Perhaps the most useful benefit of familiarizing oneself with philosophy of science and analytic philosophy is that it enables one to get a better appreciation of the difference between meaningful experimental science and sweeping generalizations deduced from shaky metaphysics.

Further reading: Five important empiricist philosophy books

We scientists are difficult, cranky, and above all, maddeningly frustrating people. Want to turn lead into gold? No problem, we can tell you how to do that, and in fact have even done it already: the only catch is that the cost of such ‘nuclear transmutation’ is many times that of even the most expensive mined gold. You say you want to travel to the moon? Done! That will be ~$80 billion (in 2005 US dollars). Want to increase average life expectancy from ~45 to ~80 years? Your wish is our command, but be mindful, you will, on average, spend the last few of those years as a fleshpot in the sunroom garden of an extended care facility.

And so it has been with an effective treatment for cerebral ischemia-reperfusion injury following cardiac arrest. Thirty years ago, laboratory scientists found a way to ameliorate most (and in many cases all) of the damage that would result from ~15 minutes of cardiac arrest, and what’s more, it was simple! All that is required is that the brain be cooled just 3oC within 15 minutes of the restoration of circulation. The catch? Well, this is surprisingly difficult thing to do because the brain is connected to the body and requires its support in order to survive. And the body, as it turns out, represents an enormous heat sink from which it is very difficult to remove the necessary amount of heat in such short time. Thus, the solution exists and has been proven in the laboratory, but it has been impossible to implement clinically.  This may be about to change as a variety of different cooling technologies, such as cold intravenous saline and external cooling of the head begin to be applied in concert with each other. Separately, they cannot achieve the required 3oC of cooling, but when added together they may allow for such cooling in a way that is both effective and practical to apply in the field.  A newly developed modality that cools the brain via the nasal cavity may provide the technological edge required to achieve the -3oC philosopher’s stone of cerebroprotection.

Read the complete article in PDF here.

19. January 2011 · Comments Off · Categories: Cryonics · Tags: , ,

Imagine that human culture has never experienced sleep, but suddenly must experience it to survive. Would they be apprehensive about experiencing it for the first time?

Of course!

Just picture… this total suspension of consciousness, experienced for the very first time in human history. The notion would totally blow our minds. It would be completely shocking. We might even make up stories about dying and being replaced by an identical clone being, or trying to console ourselves that at least we will have a successor on the following day to carry out our desires.

Contrary to popular belief, there is no particular reason to assume that humans who “survive” events like freezing or vitrification would be any different from humans that “survive” sleep or anesthesia. The definition of consciousness we care about is the lifelong continuity of experiences created by memories. We might not like donating 8 hours out of every 24 to a form of comatose oblivion, but we are able to tolerate it. We would die without it — and who wants to die?

Suppose we were to meet an alien culture that undergoes 8 hour periods of liquid nitrogen immersion every night instead of sleeping. We wouldn’t find it a significant barrier to relating to them as fellow sentient beings. We wouldn’t find it socially necessary to mourn their deaths every night or become reacquainted with their newly generated “progeny” every morning. We would just think their suspension habits are an interesting facet of their biological existence, much like they might regard our sleeping habits.

Some people seem to have the idea that cryonics patients can only be “dead” by definition — that the cessation of metabolic activity somehow makes survival via cryonics an absurdity. It is true that current cryonics patients are legally and clinically dead, but that is a matter that will probably change as scientific and social progress is made. In the mean time, there needs to be a clear distinction between destruction and deanimation — which unlike “death” are not social, legal, or philosophical terms but empirical events, much like sleep.

18. January 2011 · Comments Off · Categories: Death · Tags: , , , ,

In his book God and the Philosophers, the Austrian American atheist philosopher Paul Edwards writes:

When we die we do not return to the “bosom of Nature” or the bosom of anything. After death we will have no experiences at all for ever and ever; and this is what is so terrible about death. The fear of death is no doubt instinctive, but it is also entirely rational. The usual consolation that we also did not exist for an infinite period before birth is not really to the point. The non-existence before birth was followed by life, but our present life will not be followed by another life after we die.

Whether the fear of death is rational or not, there is also a more common sense perspective available on this issue. Fear of death seems to be hardwired in human nature, only the intensity of  this fear differs among humans. Instead of trying to overcome this fear of death with logical arguments, it would be more productive to seek meaningful rejuvenation and human enhancement therapies that would substantially reduce the probability of death by tackling aging and the fragility of human life.

It is surprising that the work of Paul Edwards has not received more attention by life extension advocates. His book Heidegger and Death and his collection of articles about Immortality indicate a serious interest in the topic of personal survival.

15. January 2011 · Comments Off · Categories: Neuroscience, Science

There are two kinds of hypothermia: protective or preservative hypothermia, and therapeutic hypothermia. The former is easy and straightforward to understand for most, clinicians and laymen, alike.  However, therapeutic hypothermia has proved to be a far more difficult idea to communicate, probably because it is so easy to conflate it with protective hypothermia.

Anyone who has had any contact with refrigeration will at once understand the concept of protective hypothermia. Foodstuffs, and other biological materials that are cooled, experience protection against spoilage and decay roughly in proportion to the degree to which they are cooled. A little cooling slows decomposition a bit, and enough cooling will stop it altogether. Again, the temperature-induced decrease in the rate of chemical reaction is a fundamental property of chemistry which is understood intuitively by anyone who lives where it gets cold, or where refrigeration is in use.

By contrast, therapeutic hypothermia does not rely primarily upon the slowing of metabolism or the rate of chemical reactions that occurs as a result of cooling, but rather upon the effects very modest degrees of cooling have on gene activation and signal transduction in mammals. Controlled, mild therapeutic hypothermia (MTH) is generally understood to constitute a reduction in body temperature from ‘normal’ for the species being treated, to 3oC below normal. In the case of humans, this would mean a reduction in body temperature from 37oC to 34oC. Such a modest reduction in temperature results in profound down-regulation of pro-inflammatory cell-signaling pathways and causes the inactivation of genes involved in a multiplicity of deleterious cellular and systemic processes. Similarly, MTH can inhibit apoptosis of brain cells, and slow or halt the downward spiral of excessive metabolic demand by injured cells, causing yet more non-productive hyper-metabolism, and consequently even more cell death. In this article, the biomechanics of MTH are briefly explored, as well as the prospects for improved outcomes in patients who suffer anoxic-ischemic brain injury as a result of cardiac arrest as a result of the rapid application of MTH following the insult.

Read the complete paper in PDF here.

13. January 2011 · Comments Off · Categories: Cryonics · Tags: , , ,

The Kurzweil Accelerating Intelligence blog features a short interview with new Alcor CEO Max More:

Q: Where do you see cryonics in the future?

We’ll look back on this 50 to 100 years from now — we’ll shake our heads and say, “What were people thinking? They took these people who were very nearly viable, just barely dysfunctional, and they put them in an oven or buried them under the ground, when there were people who could have put them into cryopreservation. I think we’ll look at this just as we look today at slavery, beating women, and human sacrifice, and we’ll say, “this was insane — a huge tragedy.”

More here.

The cryonics company Suspended Animation “will sponsor the conference, “Suspended Animation – The Company and The Goal,” which will be held in Fort Lauderdale in May, 2011. The conference will feature speakers on the latest strategies and advances toward perfecting reversible human suspended animation. During the conference, SA will also host tours and demonstrations at its facility in Boynton Beach.”

More information about the program, registration, and the free live webcast can be found on the Suspended Animation 2011 conference page.

From the conference brochure:

“The Whole-Body Vitrification Project – Greg Fahy, PhD — 21st Century Medicine, Inc. Major new findings from Phase I of a revolutionary longterm project to achieve reversible whole-body solid state suspended animation in humans. This project, conducted at 21st Century Medicine, is the only whole body vitrification research being conducted in mammals and was funded entirely by a $5.6 million dollar grant from the Life Extension Foundation. Cryobiologist Greg Fahy will discuss how well whole animals can be cryopreserved right now, the possibility of using a single advanced vitrification solution to cryopreserve entire animals and, eventually, humans, and a unique, newly-invented technology to produce large, cryopreserved tissue slices for scanning and transmission electron microscopy. A proposal and budget for Phase II of the Whole-Body Vitrification Project will also be presented.”

As we start the new year, it is helpful to draw attention to the sobering fact that no credible human rejuvenation therapies are available today, and it is doubtful that such therapies will see the light of day in the short term. Greg Fahy’s recent monumental collection of  interventive gerontology articles, The Future of Aging: Pathways to Human Life Extension (review forthcoming in Cryonics magazine), leaves little doubt about this predicament. It should also be emphasized that, with the possible exception of Robert Freitas’s comprehensive nanomedical overhaul of human biology, none of the envisioned strategies for life extension and rejuvenation (including SENS) confer increased protection to the brain in the case of severe traumatic insults or accidents. This fact alone highlights the fundamental importance of cryonics as  the core element in life extension. The idea that rejuvenation will make cryonics redundant has been one of the main obstacles for young people to engage in cryonics activism.

There is a broad consensus in the life extension community that more resources need to be allocated to combating aging as such, as opposed to increasingly futile efforts to extend life by treating aging-associated diseases. Unfortunately, the objective to launch a serious rejuvenation research program has limited mass appeal so far. As a consequence, we will have to get involved ourselves. Hopefully we can shift the focus from extensive hypothetical discussion about the consequences of human enhancement technologies to supporting and engaging in real experimental research to make these technologies facts of life.

In line with the foregoing observations, we suggest to consider the following areas for your support.

1. Cryonics. The first sensible step is making cryonics arrangements. Without cryonics arrangements you may not be able reap the benefits of anti-aging and rejuvenation treatments. Without cryonics arrangements you will remain vulnerable to a large number of personality-destroying diseases and accidents. In addition to making cryonics arrangements, support the major cryonics organizations and their research efforts.

2. Chemical Brain Preservation. Chemical brain preservation is an envisioned alternative (or complement) for human cryopreservation. At this point, there are no organizations offering chemopreservation of the brain but there is a new organization that aims to research the technical feasibility of the procedure.

3. Rejuvenation Research. The emphasis of interventive gerontology should be on rejuvenation as opposed to extending the maximum human lifespan by halting or slowing aging. Interventions aimed at rejuvenation have the distinct advantage that short-term empirical validation of their efficacy is possible. Rejuvenation therapies may include genetic manipulation, regenerative medicine, organ replacement and reversal of accumulated damage. A this stage of our knowledge, no privileged position should be claimed for any approach absent hard empirical breakthroughs in rejuvenation.

4. Nanomedicine Research. The logical evolution of medicine is to intervene at a progressively smaller scales. From “crudely” cutting into tissue, to pharmacology, to manipulating bio-molecules at the molecular level, nanomedical control of morbidity and aging is a prerequisite for resuscitation of cryonics patients and comprehensive rejuvenation. Biological and mechanical pathways to nanomedicine have been outlined. Whatever your position is on the relative technical merits and projected timelines  of such alternative approaches, the evolution of medicine into nanomedicine should be supported and accelerated.

For life—the life of any sentient creature—to be worth living, there must, as Robert Ettinger has often said, be a preponderance of satisfaction over dissatisfaction. If this overall slant toward good rather than bad is maintained, it seems reasonable that one stands to gain by continued existence. I am not sure what fraction of the human (or other sentient) population achieves this positive balance and will not speculate except to note that by appearances there are many humans who do achieve it, along with other creatures, pets in particular, so at least for them, life is worth continuing. To say that life once started is worth continuing does not, as David Benatar points out, imply that it was worth starting in the first place, or should have been started. But I think that, barring certain problematic cases,  it is fair to conclude that a human life at least is worth starting, if there are responsible prospective parents who would like to start it. Here I think it is reasonable to expect that the resulting person will feel that life is overall a benefit, and additionally, that others, the parents in particular, will stand to gain from the new life that has entered their lives. I don’t accept Benatar’s arguments that by and large life is pretty terrible and people delude themselves who think otherwise.

Also I reject his “asymmetry” argument, that it is “good” if a life that would be bad does not come into existence, but merely “not good” rather than “bad” if a life that would be good does not come into existence. (It is easy to see how this asymmetry supports the argument that life should not start in the first place and Benatar refers to it often.) Benatar’s main rationale for this argument seems to be that, while we would consider someone morally at fault for deliberately bringing into existence someone who would be miserable and just want to die, we would not similarly hold someone culpable who elected not to bring into existence someone who would be happy and want to remain alive. This I think should not be the only consideration, for it is based only on the idea of when we should regard an action as bad, and not at all on when we should regard it as good and commendable. (Why this particular asymmetry?) Instead, weighing both sides of the issue as I think is justified, I would opt for the fully symmetric position that it is “not bad” if a life that would be bad does not come into existence, and similarly, “not good” if a life that would be good does not come into existence. On the other hand, I question and doubt whether a life that comes into existence would be bad in the long run, given the prospect of immortality, which I think is a possibility through science (see below).

Life does, of course, have its problems, death in particular, that might call in question whether it is worthwhile after all and thus, whether the life of any sentient being is worth starting.  For this one problem there are a number of possible answers that will be satisfying to different people, and thus can serve as ground for a feeling that life is worthwhile and was worth starting despite one’s own mortality. There is the famous Epicurean argument that death is not really a problem because before it happens it causes no harm, and after it happens there is no victim. There is the Buddhist argument that, more fundamentally, the self is an illusion anyway, so that in fact no persons exist and death never really happens, though bliss can still occur through states of enlightenment which thus are worth seeking. There are various religious traditions that promise an afterlife and a happy immortality for those who prove worthy, or, in some versions, all who are born. Then there is scientific immortalism, which holds that at least substantial life extension through science and technology is possible, so that, irrespective of any supernatural or mystical process, persons of today have more to hope for as they get older than the usual biological ruin and oblivion.

The scientific possibilities for overcoming death come in different varieties that each have their own advocates. Some of these hopefuls, particularly younger ones, focus on the prospect that aging and now-terminal illnesses will be remedied in their natural lifetime, so that they will escape clinical death and need not specially prepare for it. Others who are not so confident have made arrangements for cryopreservation after clinical death, in hopes of resuscitation and cure of aging and diseases when the requisite technology becomes available. Still others hold out for advances on a more cosmic scale that will eventually make it possible to raise the dead comprehensively. (Some possible scenarios for this using multiple, parallel time streams rather than revisiting or recovering a hidden past are considered in my book, Forever for All, and the article at http://www.universalimmortalism.org/resurrection.htm.) The three possibilities are not mutually exclusive, so that, for example, persons who have chosen cryonics may also place varying hopes in the other two. In fact, my personal viewpoint as a scientific immortalist grants some validity to all three possibilities, but I think it is imperative now to be engaged in cryonics, which is almost unique and the clear favorite as a proactive, interventive strategy against death. Passive acceptance of the dying process simply does not feel right, whatever the prospects for near-term medical progress, or on the other hand, resurrections in a more distant, technologically superior future. It goes without saying that I also think future life will be worth living—it should be possible to make it so, if future developments can provide the opportunity.

Review of  Better Never to Have Been: The Harm of Coming into Existence by David Benatar. New York: Oxford University Press, 2006

“Would that I had never been born” is a lament sometimes voiced in the depth of misfortune, a cry of despair we hope may be soon be stilled by something more positive, when the bad things, whatever they are, have run their course. Enter David Benatar, a respected professor of philosophy at the University of Cape Town, South Africa. In the volume here reviewed he offers the extreme view that in fact it would have been better, all things considered, if not one of us had ever existed, or even any sentient life whatever. Life is that bad, he says, and he bases this judgment on certain logical principles along with empirical evidence of the allegedly poor quality of life that most of us are forced to endure in this world. Among the consequences is that no more humans should be born, and the human race (and other sentient creatures) ought to become extinct.

Antinatalism—the viewpoint that birth of sentient life, human in particular, is bad and ought not to happen, is a recurring one theme history, a noted proponent being the philosopher Arthur Schopenhauer (1788-1860). It can also be founded, as Benatar proposes, on certain assumptions considered reasonable by many people today, particularly those of a scientific, materialist outlook who are not inclined to over-optimism. Among the assumptions are that anyone’s life, overall, is an exercise in futility. Death—eternal oblivion—is the eventual fate of each person, and will happen through the normal aging process if not sooner. (Thus there is no serious prospect of a religious afterlife. Though not stated in the book, it is clear also that radical life extension, whether by imminent medical breakthroughs or through an initial “holding action” such as cryonics, is discounted.) Moreover, the human species will eventually die out, as is the fate of all biological species, so the extinction advocated by Benatar must happen in the end regardless. Another important presumption, in this case justified at length, is that in most people’s lives sorrow and misery predominate heavily over joy and happiness, so that their lives are not worth living.

Benatar denies that any good is done in any act of procreation, even if the life of the offspring is predominantly happy and if that person expresses gratitude for having been given life. The very best that could happen, Benatar says, is that no harm would be done, but only if the offspring never experienced anything bad in his/her entire life, an unlikely prospect. Even then, no good would be done or moral credit accrue in bringing that person into existence—good is done only in not bringing into existence any person who, in the course of his/her life, would at least experience some amount of bad. Harm is done, and in any likely circumstance, unacceptably serious harm, in bringing anyone into the world.

Such arguments seem unpersuasive for any of a number of reasons, and many will also find them offensive. In the matter of family planning, the prospective parents will be motivated by thoughts such as a child would bring them joy even as they in turn strive to provide the child with a happy home life and a good upbringing. Overall the child can be expected to be grateful both during the period of childhood and later in life, something that seems borne out in practice, even if hardship also occurs. As tough as the going may be at times, most people do not feel their parents were morally at fault for having had them, and are not ready to end their lives over any perceived shortcomings in their present situation or future prospects.

Benatar devotes a chapter of his book to arguing, nonetheless, that actually life as most people live it is very bad, suggesting that those who disagree don’t realize just how bad it is and are suffering some kind of delusion. But this begs the question of who is to judge. Turning the argument around, is it not possible that Benatar himself is suffering from depression that clouds his judgment? Natural selection of course favors a brighter outlook: Benatar’s thinking is not conducive to reproductive fitness. Beyond that, it is hard to see that his point of view is more “logical” than a more life-affirming one, both being based, when the rhetoric has run its course, on basic gut feelings about what is pleasant or worthwhile or isn’t, in what relative amounts, and how the mix that occurs in life should be assessed.

Despite life’s alleged wretchedness, Benatar himself is not ready to commit suicide but insists that life once started, his in particular, may be worth continuing even if it should not have been started in the first place. (Sometimes this sort of argument is reasonable. A woman should not be raped, but a child born as a consequence should not be killed.) More generally Benatar’s stance is passive rather than proactive: having children should be legal, even though no one should have them, much as we might favor allowing smoking even though it is medically and socially inadvisable.

Benatar is aware that, despite these limited concessions, his stance will be unpopular and devotes much attention to defending it against various possible lines of attack. Still it is doubtful his arguments will persuade many who are not already strongly leaning his way. The rest of us, surely a robust majority of humanity, will find our varied reasons to demur. Religious people will argue that life is a gift of God, children are a blessing, hardships and sorrows happen but can and will be remedied, all will be well in the end. Secular humanists and others of scientific bent may believe with Benatar that their lives must permanently end, and even accept the eventual extinction of all earthly life, yet still remain optimistic, one of their arguments being that “since life is finite, even sometimes very short, each moment of life, handled rightly, is precious.” Scientific immortalists who are hoping for radical life extension will also discount Benatar’s pessimism, though possibly in an odd way supporting the end of the present human species—in this case, however, by replacing it with something better that includes themselves in an enhanced form.

Meanwhile, an antinatalist movement has grown up that has simple, passive annihilation of the human species as its goal, endeavoring as far as possible to discourage everyone from having more children. In addition to a claimed humanitarian purpose—eliminating suffering as Benatar proposes—there is an environmental motive some endorse, arguing that the earth’s biosphere would greatly benefit if there were no humans to befoul it, as they generally do. Potentially a conflict could erupt between antinatalists and immortalists, who hope to be in the world for a very long time. My feeling, though, is that the antinatalist movement is both unpopular and self-limiting—on both counts, natural selection so wills it. Immortalists in any case are not so much trying to populate the planet as trying to endure as individuals. So probably we should not worry too much. Instead let’s talk to these people. Some of them (Benatar included?) may be willing to rethink their position.

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About the author: David Benatar is professor of philosophy and head of the Department of Philosophy at the University of Cape Town in Cape Town, South Africa. Though best known for his advocacy of antinatalism in his book Better Never to Have Been, he is also the author of a series of widely cited papers in medical ethics. His work has appeared in such journals as Ethics, Journal of Applied Philosophy, Social Theory and Practice, American Philosophical Quarterly, QJM: An International Journal of Medicine, Journal of Law and Religion and the British Medical Journal.